| Henry Mallow Believed to be First Ohio White Baby - Article written in 1935 | |
| 1819 | First Cemetery in Portsmouth |
| 1822 | First Presbyterian Society in the town of Portsmouth |
| 1832 | First Canal Boat from Lake Erie to Portsmouth |
| 1835 | First Towboat to Pass Portsmouth |
| 1837 | First Court House |
| 1839 | First Public School |
| 1866 | Portsmouth's First Baseball Club |
| 1880 | Portsmouth's First Telephone Company |
| 1892 | Portsmouth has longest span of telephone wire |
| 1927 | Portsmouth Has World's Largest Women's Shoe Factory |
| Portsmouth Women Invents Sewing Machine light | |
| 1932 | Telephone Company Starts First "Vacation" rate |
| 1974 | First Time Grant Bridge is Toll Free |
| 1975 | First Backpack Trail in Ohio |
| 2003 | Scioto County's First Shrimp Fest |