| Henry Mallow Believed to be First Ohio White Baby - Article written in 1935 | |
| 1819 | First Cemetery in Portsmouth | 
| 1822 | First Presbyterian Society in the town of Portsmouth | 
| 1832 | First Canal Boat from Lake Erie to Portsmouth | 
| 1835 | First Towboat to Pass Portsmouth | 
| 1837 | First Court House | 
| 1839 | First Public School | 
| 1866 | Portsmouth's First Baseball Club | 
| 1880 | Portsmouth's First Telephone Company | 
| 1892 | Portsmouth has longest span of telephone wire | 
| 1927 | Portsmouth Has World's Largest Women's Shoe Factory | 
| Portsmouth Women Invents Sewing Machine light | |
| 1932 | Telephone Company Starts First "Vacation" rate | 
| 1974 | First Time Grant Bridge is Toll Free | 
| 1975 | First Backpack Trail in Ohio | 
| 2003 | Scioto County's First Shrimp Fest |